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SUMMARY:Conventional and non-conventional methods of protein crystal growt
 h - Professor Abel Moreno
DTSTART:20090128T101500Z
DTEND:20090128T110000Z
UID:TALK16529@talks.cam.ac.uk
CONTACT:7011
DESCRIPTION:Medium-sized single crystals with near-to-perfect habits and n
 o defects that produce well resolved and intense diffraction patterns are 
 the dream of every protein crystallographer. Four basic crystallisation me
 thods are available to grow such crystals. As half a century ago in chemis
 try labs\, crystallisation assays can be set up using either (i) in batch\
 , (ii) by the diffusion of vapour between hanging (or sitting) droplets an
 d a reservoir of precipitant\, (iii) by dialysis across a semi-permeable m
 embrane or (iv) free interface diffusion at the interface of two liquids.\
 n\n \nIn this seminar an overview of crystal growth methods using convent
 ional and non-conventional experimental methods will be presented. In orde
 r to control the kinetics of the crystallisation process\, control of phys
 ical and chemical parameters allow us to control the nucleation\, and crys
 tal growth of biological macromolecules. Finally\, a short overview of the
  main counter-diffusion methods and new strategies for enhancing the cryst
 al quality for high resolution X-ray crystallography will be also revised.
  
LOCATION:Seminar Room\, Sanger Building
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