BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Protein Crystal Growth in Gels and Capillary Tubes - Professor Abe
 l Moreno
DTSTART:20090204T101500Z
DTEND:20090204T110000Z
UID:TALK16530@talks.cam.ac.uk
CONTACT:7011
DESCRIPTION:X-ray crystallography requires crystals of adequate size and q
 uality for data collection\, and their production can be the bottleneck in
  structure analysis. The problem of growing adequate crystals involves usi
 ng capillary tubes and different gel media. This has allowed the productio
 n of crystals having many less defects. Indeed\, protein and virus crystal
 s grown in such gels have enhanced diffraction properties\, including shar
 per Bragg reflections\, higher diffraction intensities with regard to the 
 background noise or a higher diffraction limit with regard to that of crys
 tals that are grown in the solution. Despite the discovery of these benefi
 ts\, gels are largely under-exploited by protein crystal growers. The same
  holds for counter diffusion\, a crystallisation method in which capillary
  forces exerted in cylindrical tubes of small diameter strongly reduce con
 vection and stabilize the concentration gradients that exist around growin
 g crystals. The aim of this seminar is to familiarize the audience with te
 chnically simple and efficient crystallisation methods for optimizing the 
 quality of crystals of a variety of biological macromolecules.
LOCATION:Seminar Room\, Sanger Building
END:VEVENT
END:VCALENDAR