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SUMMARY:Using scRNAseq to understand malaria parasite development and evol
 ution - Dr Virginia Howick 
DTSTART:20220216T160000Z
DTEND:20220216T170000Z
UID:TALK165541@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Single-cell transcriptomics has revolutionized our understandi
 ng of parasite populations. Using this technology\, we are now able to und
 erstand how a unicellular organism coordinates gene expression throughout 
 development and in response to environmental cues. I will discuss my work 
 in the Malaria Cell Atlas project\, which profiled single-cell transcripto
 mes from across the life cycles of diverse malaria parasites. I will demon
 strate how we can use these data to assign potential gene function based o
 n modules of co-expression over developmental time and identify how select
 ion may be acting at different places in the life cycle. Focusing on mosqu
 ito stage parasites\, I will show how conserved and divergent patterns of 
 gene usage between parasite species point to both essential mechanisms in 
 malaria transmission and species-specific adaptations potentially linked t
 o host tropism. Finally\, I will discuss how follow up studies have given 
 insight into functional context and have tied observed expression patterns
  to unique morphological forms.\n\nThis talk will be broadcasted via Zoom.
  Please use this "link":https://zoom.us/j/95026514738?pwd=aUtoam1zbDRYYWU0
 M1Nob2VPQXNvZz09 to gain access. 
LOCATION:Dixon  Greaves Room\, Department of Pathology\, Tennis Court Road
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