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SUMMARY:Dual transport function of mitochondrial uncoupling proteins - Pro
 fessor Elena Pohl | University of Veterinary Medicine\, Vienna 
DTSTART:20221116T150000Z
DTEND:20221116T160000Z
UID:TALK165583@talks.cam.ac.uk
CONTACT:Hannah Burns
DESCRIPTION:The mitochondrial carrier superfamily (SLC25) comprises at lea
 st 53 proteins and is the largest family of solute transporters in humans.
  Members of this family transport various solutes across the mitochondrial
  membrane\, including carboxylic acids\, amino acids\, inorganic ions\, fa
 tty acids\, C4-metabolites and nucleotides. Several family members were de
 scribed as proton transporters.\nAlthough these membrane proteins are cruc
 ial for many cellular processes\, their precise structures\, biological fu
 nctions\, and transport mechanisms remain highly controversial. I focus on
  two subfamilies: uncoupling proteins (UCP1-UCP4) and adenine nucleotide t
 ranslocase 1 (ANT1). I present a new concept for UCP expression in mammali
 an tissues\, explaining their involvement in mitochondrial metabolism. Fin
 ally\, I discuss the existing hypotheses on UCP and ANT-mediated proton tr
 ansport and present our model for ANT-mediated fatty acid (FA) anion trans
 location as part of the FA cycling mechanism.\n
LOCATION:MRC MBU\, Level 7 Lecture Theatre\, The Keith Peters Building\, C
 B2 0XY
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