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SUMMARY:BSU virtual seminar: &quot\;Assessing batch effects and their impl
 ications in single cell RNA sequencing experiments&quot\; - Prof Sarah Lan
 gley\, Lee Kong Chian School of Medicine\, NTU\, Singapore
DTSTART:20211123T120000Z
DTEND:20211123T130000Z
UID:TALK166000@talks.cam.ac.uk
CONTACT:Alison Quenault
DESCRIPTION:Single cell RNA sequencing has become an important tool for in
 vestigating cell populations and their response to conditions such as age\
 , disease or stimulation as well as the identification of novel cell popul
 ations. These sequencing experiments generate complex\, high dimensional d
 atasets which are confounded by technical and sample biases that can obscu
 re important biological effects. Adequately identifying and correcting for
  these effects is vital but given the high dimensionality\, their identifi
 cation is not always straightforward. Here I will discuss some of our ongo
 ing work in developing a geometric based methodology\, using partial Hausd
 orff distances\, for identifying these batch effects and highlight the imp
 lications these effects have on key aspects of single cell RNA-seq analysi
 s: clustering\, visualization and cell type annotation.
LOCATION:Virtual Seminar 
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