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SUMMARY:A transdiagnostic data-driven study of children’s behaviour and 
 the functional connectome - Dr Jonathan Jones
DTSTART:20211124T170000Z
DTEND:20211124T180000Z
UID:TALK166210@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Behavioural difficulties are seen as hallmarks of many neurode
 velopmental conditions. Differences in functional brain organisation have 
 been observed in these conditions\, but little is known about how they are
  related to a child’s profile of behavioural difficulties. We investigat
 ed whether behavioural difficulties are associated with how the brain is f
 unctionally organised in an intentionally heterogeneous and transdiagnosti
 c sample of 957 children aged 5-15. We used consensus community detection 
 to derive data-driven profiles of behavioural difficulties and constructed
  functional connectomes from a subset of 238 children with resting-state f
 unctional Magnetic Resonance Imaging (fMRI) data. We identified three dist
 inct profiles of behaviour that were characterised by principal difficulti
 es with hot executive function\, cool executive function\, and learning. G
 lobal organisation of the functional connectome did not differ between the
  groups\, but multivariate patterns of connectivity at the level of Intrin
 sic Connectivity Networks (ICNs)\, nodes\, and hubs significantly predicte
 d group membership in held-out data. Fronto-parietal connector hubs were u
 nder-connected in all groups relative to a comparison sample\, and childre
 n with hot vs cool executive function difficulties were distinguished by c
 onnectivity in ICNs associated with cognitive control\, emotion processing
 \, and social cognition. This demonstrates both general and specific neuro
 developmental risk factors in the functional connectome. (https://www.medr
 xiv.org/content/10.1101/2021.09.15.21262637v1)
LOCATION:Zoom
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