BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Photopharmacology: Towards Light-Controlled Therapy - Prof. Wiktor
  Szymanski\, University Medical Center Groningen
DTSTART:20211124T100000Z
DTEND:20211124T110000Z
UID:TALK166480@talks.cam.ac.uk
CONTACT:105064
DESCRIPTION:Current pharmacological treatments relay on using bioactive co
 mpounds that evoke a response by interacting with molecular targets in the
  human body. The selectivity of this interaction is crucial and the lack o
 f it leads to the emergence of severe side-effects in the body and toxicit
 y in the environment.\n\nTo solve this problem\, drugs could be introduced
  whose activity could be reversibly or irreversibly turned on with light. 
 The aim of this presentation is to describe the emerging concept of photop
 harmacology\,[1] which is currently being developed and applied to precise
 ly control the activity of drugs using light. Light offers unparalleled ad
 vantages in regulation of bioactivity and as an input/output signal in med
 ical (mostly optical/optoacoustic) imaging. Combination of those two parad
 igms along the principles of theranostics requires light-responsive tools 
 that empower both therapy and imaging.\n\nThe talk will focus on our effor
 ts towards bridging light and medicine\, focusing first on new light-opera
 ted tools[2] (molecular photoswitches[3\,4\,5] and photocages[6]. Next\, I
  will highlight the synergies between medical imaging and therapy\, offere
 d by light\, through photoresponsive optical[7] and magnetic resonance[8\,
 9] imaging agents. The examples of light-controlled bioactive molecules pr
 esented will include small molecules[10] and proteins[11]. Finally\, using
  those examples\, I will discuss the structural aspects[12] and design pri
 nciples[13] in photopharmacology.\n\n\nReferences: [1] M. W. H. Hoorens et
  al. Trends. Biochem. Sci. 43\, 567 (2018)\; [2] I. M. Welleman et al. Che
 m. Sci. 11\, 11672-11691 (2020)\; [3] L. N. Lameijer et al. Angew. Chem. I
 nt. Ed. 59\, 21663-21670 (2020)\; [4] M. W. H. Hoorens et al. Nature Comm.
  10\, 2390 (2019)\; [5] M. W. H. Hoorens et al. Chem. Sci. 12\, 4588-4898 
 (2021)\; [6] K. Sitkowska et al. ChemComm\, 56\, 5480-5483 (2020)\; [7] F.
  Reebing et al. ACS Omega 5\, 22071-22080 (2020)\; [8] F. Reebing et al. C
 urr. Opin. Biotech. 58\, 9 (2019) [9] F. Reebing et al. Chem. Comm. 55\, 1
 0784 (2019)\; [10] D. Kolarski et al. Nat. Commun. ASAP (2021)\; [11] N. M
 utter et al. J. Am. Chem. Soc. 141\, 14356 (2019)\; [12] V. Arkhipova et a
 l. J. Am. Chem. Soc.\, 143\, 1513–1520 (2021)\; [13] D. Kolarski et al. 
 Org. Biomol. Chem. 19\, 2312 – 2321 (2021).
LOCATION:https://zoom.us/j/95320855185
END:VEVENT
END:VCALENDAR