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SUMMARY:The many roles of microglia in brain wiring: a developmental persp
 ective  - Sonia Garel\, Ecole Normale Superieure\, Paris
DTSTART:20211206T160000Z
DTEND:20211206T170000Z
UID:TALK166573@talks.cam.ac.uk
CONTACT:47293
DESCRIPTION:Microglia\, the main resident immune cells of the brain\, can 
 undergo major cellular and transcriptomic changes\, a remarkable feature o
 bserved during development\, ageing and disease. Over the past decades\, m
 icroglia were shown to have key and diverse roles in brain wiring and thei
 r dysfunction has been linked to the etiology of almost all brain disorder
 s\, from neurodevelopment to neurodegeneration. Thus\, grasping how and wh
 en microglia shape circuits is important for both neurobiologists and clin
 icians. \nOur goal is to explore the contribution of microglia to early br
 ain development\, when these cells constitute a major glial population. He
 re\, we will summarize published and unpublished work highlighting emergin
 g roles of microglia in the developing brain\, including a novel role in t
 he maintenance of tissue integrity. We will discuss the implications for n
 eurodevelopmental disorders and\, more broadly\, using normal development 
 to decrypt the kaleidoscope of microglial activities and states.     \n
LOCATION:https://zoom.us/j/94405218126?pwd=MTBYZm1mKzg0NEM0b0YxREJXNWtrUT0
 9
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