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SUMMARY:From mad cows to mini brains - Cath Haig\, NIH - NIAID - RML
DTSTART:20211201T160000Z
DTEND:20211201T170000Z
UID:TALK166594@talks.cam.ac.uk
CONTACT:Alyssa Miller
DESCRIPTION:Prion diseases encompass a family of fatal neurodegenerative c
 onditions that have gained notoriety due to their transmissible nature.  P
 ublic awareness of these diseases is often limited to the variant of Creut
 zfeldt Jakob Disease that emerged following bovine spongiform encephalopat
 hy (mad cow disease) contaminated meat entering the food supply.  However\
 , these diseases more commonly arise sporadically or are hereditary.  Desp
 ite decades of research there are currently no effective treatments and fe
 w in development.  Likewise\, an understanding of the pathogenesis within 
 the human brain still eludes us and translating the findings from animal m
 odels into knowledge of human disease has been hindered by a lack of human
  model systems.  The ability to investigate prion diseases in living human
  brain tissue presented itself following the development of human cerebral
  organoids.  Cerebral organoids are spheres of brain tissue that can be gr
 own on demand in the laboratory from stem cells.  This presentation will o
 utline how the use of human cerebral organoids has advanced our examinatio
 n of neurodegeneration during prion diseases and what they might add to th
 e search for a therapy.
LOCATION:https://zoom.us/j/96577382505
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