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SUMMARY:Computational Neuroscience Journal Club - Daniel Turner-Evans and 
 Hannah Haberkern
DTSTART:20211207T150000Z
DTEND:20211207T163000Z
UID:TALK166786@talks.cam.ac.uk
CONTACT:Jake Stroud
DESCRIPTION:Please join us for our fortnightly journal club online via zoo
 m where two presenters will jointly present a topic together. The next top
 ic is ‘Uncovering the Drosophila connectome’ presented by Daniel Turne
 r-Evans (UC Santa Cruz & Janelia) and Hannah Haberkern (Janelia).\n\nZoom 
 information: https://us02web.zoom.us/j/84958321096?pwd=dFpsYnpJYWVNeHlJbEF
 KbW1OTzFiQT09 Meeting ID: 849 5832 1096 Passcode: 506576\n\nSummary:\nRece
 ntly\, two fruit fly brains were imaged with electron microscopy down to t
 he level of individual synapses. Automated techniques were then used to re
 construct the constituent neurons and to identify connections between them
 \, providing a connectome of various brain regions. Crucially\, these data
 sets contain the recurrent neural network structure of the entire fly navi
 gation center\, from sensory inputs all the way to motor outputs. A detail
 ed analysis of this network identified circuit motifs that shape informati
 on as it flows through the network. These motifs likely 1) filter sensory 
 inputs before using them to update a working memory of the fly’s head di
 rection\, 2) perform vector arithmetic to convert head direction to body d
 irection 3) use the body direction signal to update working memories of de
 sired goal locations\, and 4) compare a goal location to the animal’s on
 going movements to drive behavior. Two of the study’s lead authors will 
 discuss these motifs and other insights that emerged from analyzing the fl
 y connectome.\n\nRelevant reading:\n\nHulse\, Haberkern\, Franconville & T
 urner-Evans et al.: “A connectome of the Drosophila central complex reve
 als network motifs suitable for flexible navigation and context-dependent 
 action selection”.\n\nScheffer et al.: “A Connectome of the Adult Dros
 ophila Central Brain”.\n\nTurner-Evans & Jayaraman: “The insect centra
 l complex”.
LOCATION:Online on Zoom
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