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SUMMARY:Stress deceleration theory: chronic adolescent stress exposure res
 ults in decelerated neurobehavioral maturation - Kshitij Jadhav\, Departme
 nt of Psychology\, University of Cambridge
DTSTART:20220119T170000Z
DTEND:20220119T180000Z
UID:TALK166927@talks.cam.ac.uk
CONTACT:Katharina Zuhlsdorff
DESCRIPTION:Normative development in adolescence indicates that the prefro
 ntal cortex is still under development thereby unable to exert efficient t
 op-down inhibitory control on subcortical regions such as the basolateral 
 amygdala and the nucleus accumbens. This imbalance in the developmental tr
 ajectory between cortical and subcortical regions is implicated in express
 ion of the prototypical impulsive\, compulsive\, reward seeking and risk-t
 aking adolescent behavior. Here we demonstrate that a chronic mild unpredi
 ctable stress procedure during adolescence in male Wistar rats arrests the
  normal behavioral maturation such that they continue to express adolescen
 t-like impulsive\, hyperactive\, and compulsive behaviors into late adulth
 ood. This arrest in behavioral maturation is associated with the hypoexcit
 ability of prelimbic cortex (PLC) pyramidal neurons and reduced PLC-mediat
 ed synaptic glutamatergic control of BLA and nucleus accumbens core (NAcC)
  neurons that lasts late into adulthood. At the same time stress exposure 
 in adolescence results in the hyperexcitability of the BLA pyramidal neuro
 ns sending stronger glutamatergic projections to the NAcC. Chemogenetic re
 versal of the PLC hypoexcitability decreased compulsivity and improved the
  expression of goal-directed behavior in rats exposed to stress during ado
 lescence\, suggesting a causal role for PLC hypoexcitability in this stres
 s-induced arrested behavioral development. (https://www.biorxiv.org/conten
 t/10.1101/2021.11.21.469381v1.abstract)
LOCATION:Zoom
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