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SUMMARY:Constructing 4D molecular roadmaps of cell fate decisions - Dr Eff
 ie Apostolou\; Associate Professor of Molecular Biology in Medicine\, Weil
 l Cornell Medical College
DTSTART:20220209T150000Z
DTEND:20220209T160000Z
UID:TALK167065@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Effie Apostolou studied Biology in the Aristotle University of
  Thesaloniki in Greece (1998-2003) and did her PhD studies in Dimitris Tha
 nos lab in Athens on mechanisms that regulate stochastic gene expression u
 pon virus induction (Apostolou and Thanos\, Cell 2008). In 2009\, she join
 ed Konrad Hochedlinger lab in MGH and Harvard Stem Cell institute in Bosto
 n to unravel epigenetic mechanisms that drive somatic cell reprograming to
  iPSCs (Apostolou*\, Ferarri* et al\, Cell Stem Cell 2013\; Stadtfeld*\, A
 postolou* et al\, Nature 2010\; Stadtfeld*\, Apostolou* et al\, Nat. Gen. 
 2012). \n\nShe is currently an Associate Professor of Molecular Biology at
  Weill Cornell Medicine\, which I joined in 2014. The main focus of her gr
 oup is to dissect the critical interplay between TFs\, 3D chromatin organi
 zation and transcription during either (i) maintenance of cell fate (self-
 renewal) or (ii) during transition to a new fate. The Apostolou group rece
 ntly constructed the first integrative\, genome-wide map of the dynamic ar
 chitectural and transcriptional changes that occur upon mitotic exit to en
 sure faithful propagation of stem cell identity and functionally interroga
 ted the role of mitotic bookmarking in this process (Molecular Cell\, 2021
 \; Stem Cell Reports 2020\; Cell Reports 2017). Her group has also shown t
 hat transcription factors\, such as KLF4\, play important roles in the org
 anization and transcriptional regulation of 3D enhancer hubs (Di Giammarti
 no et al\, Nature Cell Biology 2019). \n\nEffie Apostolou has received sev
 eral awards\, including Jane Coffins Child Foundation and EMBO postdoctora
 l fellowships and the NIH Director’s New Innovator award and the Emergin
 g Leader award from the Mark Foundation.\n\nClick here to join live - http
 s://us06web.zoom.us/j/82247631005 
LOCATION:Online via zoom
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