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SUMMARY:Regulatory evolution by transcription-factor duplication - Profess
 or Naama Barkai\; Dept. of Molecular Genetics\, Weizmann Institute of Scie
 nce 
DTSTART:20220127T123000Z
DTEND:20220127T133000Z
UID:TALK167068@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:Throughout evolution\, new transcription factors (TFs) emerge 
 by gene duplication\, promoting growth and rewiring of transcriptional net
 works. How TF duplicates diverge was studied in a few cases only. To provi
 de a genome-scale view\, we considered the set of budding yeast TFs classi
 fied as whole-genome duplication (WGD)-retained paralogs (~35% of all spec
 ific TFs). Using high-resolution profiling\, we find that ~60% of paralogs
  evolved differential binding preferences. We show that this divergence re
 sults primarily from variations outside the DNA binding domains (DBDs)\, w
 hile DBD preferences remain largely conserved. Analysis of non-WGD ortholo
 gs revealed uneven splitting of ancestral preferences between duplicates\,
  and the preferential acquiring of new targets by the least conserved para
 log (biased sub/neo-functionalization). Interactions between paralogs were
  rare\, and\, when present\, occurred through weak competition for DNA-bin
 ding or dependency between dimer-forming paralogs We discuss the implicati
 ons of our findings for the evolutionary design of transcriptional network
 s.\n\nClick here to join live - https://us06web.zoom.us/j/83688166215 
LOCATION:Online via zoom
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