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SUMMARY:Better multiple sequence alignment by being phylogeny-aware\, and 
 better base calling from next-generation sequencers - Nick Goldman (EMBL-E
 uropean Bioinformatics Institute)
DTSTART:20090128T150000Z
DTEND:20090128T160000Z
UID:TALK16717@talks.cam.ac.uk
CONTACT:Danielle Stretch
DESCRIPTION:I will describe two distinct research projects from my group a
 t EBI.  In the first\, I will show how a simple flaw in progressive multip
 le alignment algorithms has led to alignment errors for many years.  The e
 rror is easily corrected\; scientists' expectations of what a good alignme
 nt should look like may take longer to change.  In the second\, I will des
 cribe how the Solexa/Illumina Genome Analyzer sequencing platform works\, 
 some of the processes that lead to errors in its short-read sequences and 
 how inference based on mathematical modelling of these errors has led to i
 mproved results.\n
LOCATION:MR5\, Centre for Mathematical Sciences\, Wilberforce Road\, Cambr
 idge
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