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SUMMARY:Can We Rewrite Maladaptive Memories? The Potential and Challenges 
 of Harnessing Memory Reconsolidation as a Therapeutic Target in Mental Hea
 lth - Dr Ravi Das\, University College London
DTSTART:20220310T123000Z
DTEND:20220310T133000Z
UID:TALK167216@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:* Maladaptive memories are thought to play a key rol
 e in ‘acquired’ mental health disorders like addiction\, PTSD and phob
 ia\, by eliciting maladaptive responses (e.g. craving) in response to envi
 ronmental triggers.  Such ‘maladaptive memories’ are therefore thought
  to be a key transdiagnostic therapeutic target for relapse prevention in 
 several disorders. However\, we do not currently have therapies that can e
 ffectively silence maladaptive memories\, with return of maladaptive behav
 iour being typical following current ‘exposure therapies’. I will pres
 ent clinical translational work examining the potential of silencing estab
 lished memories via the process of ‘reconsolidation’\, during which me
 mories become briefly unstable and open to interference.  This will highli
 ght pharmacological and behavioural approaches to modifying memories and e
 arly clinical assessments of reconsolidation as a therapeutic mechanism. B
 oth translational successes and failures will be discussed to highlight th
 e key challenges ahead and make recommendations for bringing memory plasti
 city-based therapies to the clinic.  \n\n*Biography:* Dr. Ravi Das is an A
 ssociate Professor in Psychopharmacology and Joint Director of the Clinica
 l Psychopharmacology Unit at University College London. His research aims 
 to translate insights into the mechanisms of neural and behavioural plasti
 city into improved treatments for mental health disorders. This primarily 
 focuses on maladaptive learning and memory\, using behavioural and drug ap
 proaches to assess candidate new candidate treatments in an experimental m
 edicine setting. For detailed biography of Dr Das\, please visit: https://
 www.ucl.ac.uk/educational-psychology/people/ravi_das.html
LOCATION:Zoom (Please contact mho28@medschl.cam.ac.uk)
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