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SUMMARY:Genome Organization through Phase Separation: Random yet Precise -
  Dr Bin Zhang\, Massachusetts Institute of Technology
DTSTART:20220119T143000Z
DTEND:20220119T153000Z
UID:TALK167447@talks.cam.ac.uk
CONTACT:Lisa Masters
DESCRIPTION:The three-dimensional genome organization plays an essential r
 ole in all DNA -templated processes\, including gene transcription\, gene 
 regulation\, DNA replication\, etc. Coarse-grained models parameterized to
  reproduce experimental data via the maximum entropy optimization algorith
 m serve as effective means to study genome organization at various length 
 scales. They have provided insight into the principles of whole-genome org
 anization and enabled de novo predictions of chromosome structures from ep
 igenetic modifications. In addition\, they provided insight into the criti
 cal role of the chromatin network in stabilizing multiple liquid droplets.
  Applications of these models at a near-atomic resolution further revealed
  physicochemical interactions that drive the phase separation of disordere
 d proteins and dictate chromatin stability in situ.
LOCATION:via zoom 
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