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SUMMARY:From building blocks to systems: where do we go next? - Sarath Jan
 ga\, MRC Laboratory of Molecular Biology
DTSTART:20090205T130000Z
DTEND:20090205T134500Z
UID:TALK16793@talks.cam.ac.uk
CONTACT:Dr James Kirkbride
DESCRIPTION:All living systems orchestrate their response to external cond
 itions\, grow and give rise to their offspring using essentially the same 
 set of basic elements like DNA\, RNA and Protein. Indeed\, most of the stu
 dies in pre-genomic era have seen biological systems as parts of the whole
  cell and have been greatly successful in characterizing the underlying me
 chanisms for a great number of these parts-list. However\, an important no
 tion that is emerging in post-genomic biology is that cellular components 
 do not work in isolation and hence can be visualized as a dense and comple
 x network of interactions between different molecules like genes\, protein
 s\, DNA and metabolites in the cell without isolating any subset.  This ha
 s led to the application of network theory to a wide range of biological p
 roblems from understanding cellular dynamics to diseases. In this short ta
 lk\, I will first present some basic concepts of molecular biology and the
  paradigm shifts that have occurred in their understanding with the availa
 bility of genomic sequences and high-throughput technologies. In the later
  part\, I will introduce the notion of networks and systems in biology --b
 ringing up the concept of systems biology and discuss future avenues in th
 is promising field. 
LOCATION:Entertaining Room\, Darwin College
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