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SUMMARY:Identification of ancient silks using proteomics and immunoassays 
 - Bing Wang\, Institute of Textile Conservation\, Zhejiang Sci-Tech Univer
 sity\, Hangzhou
DTSTART:20220121T131500Z
DTEND:20220121T140000Z
UID:TALK168971@talks.cam.ac.uk
CONTACT:Ruairidh Macleod
DESCRIPTION:The production of silk is generally believed to originate in t
 he Neolithic period\nwithin the Yangshao culture (3th-5th millennium BC). 
 However\, the true origin and\nspread of silk remains an unsolved mystery 
 to this day. This is because silk is mainly\ncomposed of silk fibroin and 
 a small amount of other proteins. These proteins are\neasily degraded unde
 r the action of temperature\, humidity\, light and microorganisms\,\nmakin
 g it difficult to find physical evidence of silk in archaeological sites. 
 In recent\nyears\, Dr. Wang's research group analyzed the amino acid seque
 nce structure of silk\nfibroin through proteomics and found many tissue an
 d taxonomically specific peptides of ancient silk. Using\nthese diagnostic
  sequences as immunogens\, a series of polyclonal and monoclonal\nantibodi
 es that can specifically recognize ancient silk were prepared by animal\ni
 mmunization. On this basis\, a variety of immunological techniques and pro
 ducts\nsuitable for laboratories and archaeological sites have been develo
 ped\, i.e.\, ELISA\,\nimmunofluorescence microscopy\, Western Blot\, immun
 ochromatographic assay kits\nand immunosensors. These methods not only pro
 vide powerful analytical tools for\nstudying the origin and dissemination 
 of ancient silk\, but also provide references for\nthe study of other type
 s of protein artifacts.
LOCATION:Online via zoom: https://cam-ac-uk.zoom.us/meeting/register/tJArd
 -2vqDssGN3r3r9JzlCL9w3NoHlB21an 
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