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SUMMARY:Getting into shape: new insights into morphological patterning fro
 m the Drosophila wing - Natalie Dye (POL Dresden) 
DTSTART:20220307T143000Z
DTEND:20220307T153000Z
UID:TALK169010@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:How cellular activity is coordinated over long spatial and tem
 poral timescales to build complex 3D tissue morphologies during animal dev
 elopment remains a fascinating open question in biology. We study collecti
 ve cellular behavior during epithelial morphogenesis using the Drosophila 
 wing as a model. At the transition between larval and pupal stages\, the d
 eveloping wing tissue undergoes a complex 3D remodeling process called eve
 rsion\, where deep tissue folds unfold and the dorsal and ventral surfaces
  find each other and appose. Using confocal and multi-angle light sheet mi
 croscopy\, we have quantified the patterns of cell and tissue shape change
 s occurring during this process. Our data suggest that spatial patterns of
  cell morphology that emerge during the larval growth phase may prepone pa
 rticular 3D tissue shape changes during the subsequent eversion stage. We 
 are testing this idea using theoretical approaches and genetic perturbatio
 n. This work broadens our understanding of tissue morphogenesis by describ
 ing a novel interplay between cellular packing geometry and 3D tissue shap
 e changes. 
LOCATION:Online
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