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SUMMARY:Identification of ancient silks using proteomics and immunoassays 
 - Bing Wang\, Zhejiang Sci-Tech University
DTSTART:20220121T131500Z
DTEND:20220121T140000Z
UID:TALK169022@talks.cam.ac.uk
CONTACT:Ruairidh Macleod
DESCRIPTION:The production of silk is generally believed to originate in t
 he Neolithic period within the Yangshao culture (3th-5th millennium BC). H
 owever\, the true origin and spread of silk remains an unsolved mystery to
  this day. This is because silk is mainly composed of silk fibroin and a s
 mall amount of other proteins. These proteins are easily degraded under th
 e action of temperature\, humidity\, light and microorganisms\, making it 
 difficult to find physical evidence of silk in archaeological sites. In re
 cent years\, Dr. Wang's research group analyzed the amino acid sequence st
 ructure of silk fibroin through proteomics and found many tissue and taxon
 omically specific peptides of ancient silk. Using these diagnostic sequenc
 es as immunogens\, a series of polyclonal and monoclonal antibodies that c
 an specifically recognize ancient silk were prepared by animal immunizatio
 n. On this basis\, a variety of immunological techniques and products suit
 able for laboratories and archaeological sites have been developed\, i.e.\
 , ELISA\, immunofluorescence microscopy\, Western Blot\, immunochromatogra
 phic assay kits and immunosensors. These methods not only provide powerful
  analytical tools for studying the origin and dissemination of ancient sil
 k\, but also provide references for the study of other types of protein ar
 tifacts.\n\nPlease register in advance for the zoom link for this seminar:
 \nhttps://cam-ac-uk.zoom.us/meeting/register/tJIofuiqqT8sHdJl2pILkGv8NbF1E
 CD2WuTY
LOCATION:Online via zoom
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