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SUMMARY:How to Sequence 1000 Human Genomes Efficiently - Professor Richard
  Durbin\, Sanger Institute\, Hinxton
DTSTART:20090216T170000Z
DTEND:20090216T180000Z
UID:TALK16989@talks.cam.ac.uk
CONTACT:Professor Nicholas S. Manton
DESCRIPTION:DNA sequencing output has scaled superexponentially for three 
 decades\, with average doubling time since 1980 of 16 months\, and more ra
 pid doubling recently. We have reached the point where it is now possible 
 to sequence hundreds of human genomes in order to develop a much more comp
 lete picture of human genetic variation\nthat will underpin future researc
 h in human genetics. The design of this experiment\, and analysis of the d
 ata\, need to take account of the pattern of genetic differences shared be
 tween individuals\, as well as efficient sequence matching and statistical
 \nanalysis. I will discuss recently developed methods based on Ancestral R
 ecombination Graphs (the data structure underlying the coalescent with rec
 ombination) and how we are using them to analyse data from the 1000 Genome
 s Project <www.1000genomes.org>\, and introduce some related problems.\n
LOCATION:MR2\, Centre for Mathematical Sciences
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