BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Chemically modifying surfaces and biomolecules for nanopore analys
 is - Dr Stefan Howorka\, Department of Chemistry\, University College Lond
 on
DTSTART:20090605T131500Z
DTEND:20090605T141500Z
UID:TALK17019@talks.cam.ac.uk
CONTACT:Jurij Kotar
DESCRIPTION:Nanopores analytics is an attractive electrical technique. In 
 nanopore \nanalytics\, individual molecules pass through a nanopore and ca
 use \ndetectable changes in pore conductance. Chemistry can be applied to 
 \nenhance nanopore analytics. Firstly\, small chemical tags can be attache
 d \nto analyte molecules to generate a unique current signature. This has 
 \nbeen exemplary demonstrated by linking chemical tags to bases in DNA \ns
 trands. The tags caused unique current blockades thereby enabling the \nde
 tection of individual bases in translocating DNA strands. In addition\, \n
 chemistry is expected to help tailor the properties of solid-state \nnanop
 ores. Surface engineering has the potential\, for example\, to avoid \nthe
  undesired non-specific interaction between analytes and the pores. \nIn a
 ddition\, chemistry is also capable of engineering defined analyte \nrecog
 nition sites into blank pores. Based on recent work on the chemical \nmodi
 fication of planar substrates\, examples are given on how coatings \ncompo
 sed of hydrophilic polymers improve the properties of inorganic \nsurfaces
 .
LOCATION:Small Lecture Theatre\, Cavendish Laboratory
END:VEVENT
END:VCALENDAR