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SUMMARY:Thoughts that go bump in the night: sleep-sensitive circuits in ps
 ychiatry - Prof Matt Jones\, University of Bristol
DTSTART:20220512T113000Z
DTEND:20220512T123000Z
UID:TALK170273@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:* The non-REM sleep EEG of schizophrenia patients co
 nsistently reveals abnormal thalamocortical sleep spindles and slow-waves.
  These oscillatory signatures constitute non-invasive\, translational metr
 ics of schizophrenia neurobiology\, potentially illuminating mechanistic r
 outes between risk factors\, brain development\, neural circuit dysfunctio
 n\, symptoms and personalised therapies. However\, grappling with complexi
 ty\, heterogeneity and causality remains challenging.\n\nI will introduce 
 our approach to iterating between deep-brain\, cellular-resolution neuroph
 ysiology in rodents and scalp EEG in genotyped volunteers and patients\, m
 ost recently in young people with 22q11.2 deletion syndrome. Sleep does no
 t hold all the answers\, but I hope to make the case that integrating slee
 p neurophysiology into translational psychiatry can expedite understanding
  of the neurobiology of individual patients\, optimising their diagnosis a
 nd treatment.\n\n*Biography:* Prof Matt Jones trained as a neuroscientist 
 at the University of Cambridge\, the UK National Institute for Medical Res
 earch and the Massachusetts Institute of Technology before establishing hi
 s research team at the University of Bristol.  His lab strives to understa
 nd how distributed neural networks spanning hippocampus\, striatum and pre
 frontal cortex process and store information\, and how this processing bec
 omes impaired in neuropsychiatric disorders.  To do this\, they record and
  modulate brain activity using arrays of electrodes in rodents\, genotyped
  volunteers and patients\, then apply computational modelling and analyses
  to try and decode the terabytes.  Current projects include analyses of sl
 eep’s contributions to cognition\, the diagnostic and translational util
 ity of sleep neurophysiology and the circuit architecture of psychedelic d
 rug action. For detailed biography of Prof Jones\, please visit: https://r
 esearch-information.bris.ac.uk/en/persons/matt-w-jones
LOCATION: Webinar  (via Zoom online)
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