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SUMMARY:Controlling Drug Transport With Pharmaceutical Nanotechnology  - P
 rofessor Ijeoma F. Uchegbu | UCL School of Pharmacy
DTSTART:20220315T180000Z
DTEND:20220315T193000Z
UID:TALK170375@talks.cam.ac.uk
CONTACT:92260
DESCRIPTION:Insights into in vivo drug transport mechanisms and their cont
 rol\, using pharmaceutical nanotechnology\, allow for the development of e
 fficacious and safer medicines. Over the past two decades\, we have design
 ed self-assembling polymers and peptides from a variety of chemistries and
  used these new molecules to produce nano-enabled candidate medicines aime
 d at particular unmet clinical needs.  \nLately\, we have focused on the d
 esign of pain medicine\, in which the endogenous and metabolically labile 
 peptide\, enkephalin\, is packaged in pharmaceutical nanoparticles and del
 ivered to the brain\; resulting in the candidate medicine - Envelta™.  E
 nvelta™ has a number of differentiating features and has been out-licens
 ed for clinical development\, in an effort to address the US opioid crisis
 \, as prescription opioid use in the US is responsible for 15\,000 deaths 
 per annum.  \nWe have also developed nano-enabled ocular technologies\, as
  drug delivery to ocular tissues is inefficient due to the very short ocul
 ar residence time (1-2 minutes) and eye drops cannot be used to target the
  back of the eye.  Our nano-enabled eye drops deliver drugs to the retina 
 and significantly enhance drug deposition into ocular tissues\, with no pl
 asma exposure.  The use of eye drops to deliver drugs to the retina is unp
 recedented and could lead to more effective treatments for retinal disease
 s.  One of these new candidate medicines will enter clinical development i
 n 2021.\n  \nOther outputs from our laboratory include a biocompatible nas
 al spray that significantly inhibits respiratory viruses18 and a new diagn
 ostic platform\, which enables high-resolution imaging of the liver vascul
 ature.   
LOCATION:Wolfson Lecture Theatre\,  Department of Chemistry\, Lensfield Ro
 ad
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