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SUMMARY:The cell-physiological constraints of microbial growth in and out 
 of steady-state - Jonas Cremer (Stanford University - California)
DTSTART:20220308T170000Z
DTEND:20220308T180000Z
UID:TALK170450@talks.cam.ac.uk
CONTACT:Margarida Rodrigues
DESCRIPTION:Efficient growth is central for microbial life and microbes th
 us  need to coordinate their cell-machinery for rapid biomass accumulation
 . In this talk I discuss recent advances in understanding this coordinatio
 n. Via the lens of a low-dimensional theory I particularly consider how gr
 owth is shaped by a balance between protein synthesis (via ribosomes) and 
 the metabolic processes which are needed to sustain ribosomal activity. An
  extensive comparison with data from Escherichia coli establishes the theo
 ry and  shows how cells adjust the balance between metabolism and ribosome
  activity  to navigate the constraints of protein-synthesis in steady and 
 changing conditions.  Our findings confirm that the ribosome content in th
 e cell is tuned to best cope with the encountered condition but many prote
 ins which support metabolic processes are more broadly expressed across co
 nditions even if not needed. This combination of optimal and (apparently) 
 non-optimal behavior explains many growth phenotypes\, including the ‘gr
 owth-law’ relating ribosome content with growth-rate and long lags in gr
 owth when conditions shift.\n\nRegistration\nhttps://us02web.zoom.us/meeti
 ng/register/tZ0rde-hqz8pH9H_bakTKFv6i5nbvgoAwjKr\n
LOCATION:Zoom (see registration link below)
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