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SUMMARY:Brain charts for the human lifespan - Dr Richard Bethlehem\, Unive
 rsity of Cambridge
DTSTART:20220505T113000Z
DTEND:20220505T123000Z
UID:TALK171107@talks.cam.ac.uk
CONTACT:87079
DESCRIPTION:*Abstract:* Over the past few decades\, neuroimaging has becom
 e a ubiquitous tool in basic research and clinical studies of the human br
 ain. However\, no reference standards currently exist to quantify individu
 al differences in neuroimaging metrics over time\, in contrast to growth c
 harts for anthropometric traits such as height and weight1. Here we assemb
 le an interactive open resource to benchmark brain morphology derived from
  any current or future sample of MRI data (http://www.brainchart.io/). Wit
 h the goal of basing these reference charts on the largest and most inclus
 ive dataset available\, acknowledging limitations due to known biases of M
 RI studies relative to the diversity of the global population\, we aggrega
 ted 123\,984 MRI scans\, across more than 100 primary studies\, from 101\,
 457 human participants between 115 days post-conception to 100 years of ag
 e. MRI metrics were quantified by centile scores\, relative to non-linear 
 trajectories2 of brain structural changes\, and rates of change\, over the
  lifespan. Brain charts identified previously unreported neurodevelopmenta
 l milestones3\, showed high stability of individuals across longitudinal a
 ssessments\, and demonstrated robustness to technical and methodological d
 ifferences between primary studies. Centile scores showed increased herita
 bility compared with non-centiled MRI phenotypes\, and provided a standard
 ized measure of atypical brain structure that revealed patterns of neuroan
 atomical variation across neurological and psychiatric disorders. In summa
 ry\, brain charts are an essential step towards robust quantification of i
 ndividual variation benchmarked to normative trajectories in multiple\, co
 mmonly used neuroimaging phenotypes.\n\n*Biography:* Dr Richard Bethlehem 
 is currently a Research Associate at the Brain Mapping Unit and Director o
 f Neuroimaging at the Autism Research Centre\, both in the Department of P
 sychiatry at the University of Cambridge. His research aims at gaining a b
 etter understanding of genetic underpinnings of typical and atypical neuro
 development by integrating cutting-edge neuroimaging and transcriptomics t
 echniques. Increasingly\, this involves the use of large neuroimaging and 
 genetic datasets such as the UK BioBank and ABCD cohorts as well as machin
 e learning methods to delineate highly complex data. In Cambridge he maint
 ains close collaboration with Profs. Bullmore and Baron-Cohen as well as w
 ith Prof. Pietro Lio at the Computer Sciences department at Cambridge\, th
 e Geschwind and Gandal labs at UCLA\, the Multimodal Imaging and Connectom
 e Analysis lab at the MNI led by Dr. Boris Bernhardt\, the Brain-Gene-Deve
 lopment lab at the CHOP Research Institute led by Dr. Aaron Alexander-Bloc
 h as well as with The University of York through his collaboration with Pr
 of. Beth Jefferies. For detailed biography of Dr Bethlehem\, please visit:
  https://www.autismresearchcentre.com/staff/richard-bethlehem/
LOCATION:Zoom (Please contact mho28@medschl.cam.ac.uk)
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