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SUMMARY:Heart disease link to lack of oxygen in the womb - Dr Dino Giussan
 i\, Dep. of Physiology\, Development and Neuroscience
DTSTART:20090401T105500Z
DTEND:20090401T112000Z
UID:TALK17125@talks.cam.ac.uk
CONTACT:Gigi Moller
DESCRIPTION:Heart disease is the greatest killer in the UK today\, imposin
 g a substantial burden on the nation's health and wealth. In addition to t
 he interaction between genetic makeup and lifestyle risk factors\, another
  concept in determining susceptibility to heart disease has now become est
 ablished - one of developmental programming. This states that a component 
 of both the cardiovascular health we enjoy and the risk of heart disease i
 n adult life can be predetermined before birth\, not only by our genes but
  also by their interaction with the quality of the prenatal environment.  
 The mechanisms underlying the developmental programming of cardiovascular 
 disease in complicated pregnancy remain unknown\, preventing the identific
 ation of potential therapeutic targets for clinical intervention.  Prenata
 l hypoxia is a common feature of complicated pregnancy.  Building on a wea
 lth of human and experimental data\, the work presents the thesis that oxi
 dative stress underlies the molecular basis via which prenatal hypoxia con
 tributes to the developmental programming of cardiovascular disease.  Usin
 g an integrative approach at the systems\, isolated organ\, cellular and m
 olecular levels the data show that reductions in oxygen delivery to the un
 born can increase its risk of developing heart disease later in life\, and
  that treatment of complicated pregnancies with antioxidants can protect a
 gainst this.  The work offers the potential for therapeutic targets for cl
 inical intervention against a developmental origin of heart disease in ris
 ky pregnancy.
LOCATION:Centre for Mathematical Sciences\, Meeting Room 2
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