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SUMMARY:Exploring mechanisms of human brain expansion in cerebral organoid
 s - Dr Madeline Lancaster MRC Laboratory of Molecular Biology
DTSTART:20220517T150000Z
DTEND:20220517T160000Z
UID:TALK171599@talks.cam.ac.uk
CONTACT:Dr Dervila Glynn
DESCRIPTION:*Theme: Lifelong Brain Development*\n\n*Abstract:*The human br
 ain sets us apart as a species\, with its size being one of its most strik
 ing features. Brain size is largely determined during development as vast 
 numbers of neurons and supportive glia are generated. In an effort to bett
 er understand the events that determine the human brain’s cellular makeu
 p\, and its size\, we use a human model system in a dish\, called cerebral
  organoids. These 3D tissues are generated from pluripotent stem cells thr
 ough neural differentiation and a supportive 3D microenvironment to genera
 te organoids with the same tissue architecture as the early human fetal br
 ain. Such organoids are allowing us to tackle questions previously impossi
 ble with more traditional approaches. Indeed\, our recent findings provide
  insight into regulation of brain size and neuron number across ape specie
 s\, identifying key stages of early neural stem cell expansion that set up
  a larger starting cell number to enable the production of increased numbe
 rs of neurons. We are also investigating the role of extrinsic regulators 
 in determining numbers and types of neurons produced in the human cerebral
  cortex. Overall\, our findings are pointing to key\, human-specific aspec
 ts of brain development and function\, that have important implications fo
 r neurological disease.\n\nRegister in advance for this seminar: https://u
 s02web.zoom.us/meeting/register/tZUodeyoqzsoHt3jbjh3UrPY4ZPrHsWWWfXR\n\nAf
 ter registering\, you will receive a confirmation email containing informa
 tion about joining the meeting.
LOCATION:Register on Zoom - link in abstract
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