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SUMMARY:CPB Seminar - Marcus Taylor - Marcus Taylor (MPI for Infection Bio
 logy\, Berlin)
DTSTART:20220714T090000Z
DTEND:20220714T100000Z
UID:TALK172067@talks.cam.ac.uk
CONTACT:Margarida Rodrigues
DESCRIPTION:Higher-order oligomeric assembly in the innate immune system: 
 Myddosome assembly and the induction of inflammation\n\nThe Myddosome is a
  specialized innate immune signaling complex that activates NF-kB signalin
 g. Critical to NF-kB activation is the formation of lysine-63 and methioni
 ne-1 linked polyubiquitin chains. How does the Myddosome control the forma
 tion of these two distinct polyubiquitin chains to activate NF-kB signalin
 g? In this talk\, I will describe how we have discovered that Myddosomes a
 re plasma membrane-tethered organelles that concentrate and activate the p
 rotein machinery that assembles K63/M1 polyubiquitin chains. We discovered
  that the spatial reorganization of Myddosomes into clusters regulates the
  formation of M1/K63 ubiquitin chains and the activation of NF-kB signalin
 g. Inhibiting Myddosome clustering reduced the recruitment of the K63 ubiq
 uitin ligases TRAF6 and the M1 ubiquitin ligase HOIL1. Finally\, I will de
 scribe our efforts to create a spatial and temporal map of the IL-1-Myddos
 ome signaling network. These efforts seek to understand how extracellular 
 signalling triggers the assembly of the Myddosome and how the stoichiometr
 ic composition of oligomeric signaling complexes remodels in time.
LOCATION:Sainsbury Laboratory \, Auditorium\, 47 Bateman Street \, CB2 1LR
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