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SUMMARY:Composite morphogenesis: how can a tissue fold and extend at the s
 ame time     - Matteo Rauzi (IBV\, Nice)
DTSTART:20220425T133000Z
DTEND:20220425T143000Z
UID:TALK173210@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:During embryo development\, epithelia can undergo different sh
 ape transformations. While these changes can be sequential\, and thus driv
 en by specific sequential cellular mechanisms\, this is not always the cas
 e. A single tissue can undergo multiple simultaneous shape transformations
  resulting in a composite process. For instance\, in vertebrates\, during 
 neurulation\, the dorsal tissue folds forming the neural tube while elonga
 ting along the anterior-posterior axis separating the future head from the
  anus (Keller\, 2002). This raises an important question: how can a tissue
  undergo multiple simultaneous shape transformations if each transformatio
 n is per se driven by different and functionally specific cellular mechani
 sms? In addition\, which signaling pathways are controlling composite morp
 hogenetic processes? We use the early gastrulating Drosophila embryo as mo
 del system and focus on the process of mesoderm invagination during which 
 the tissue on the ventral side of the embryo simultaneously folds and exte
 nds. By using advanced multi-view light sheet microscopy coupled to infrar
 ed femtosecond laser manipulation\, optogenetics and quantitative big data
  analysis\, we shed new light on the genetic synergy\, the mechanisms and 
 mechanics controlling and driving composite morphogenesis. \n\n 
LOCATION:Online
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