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SUMMARY:Finding a needle in a haystack: Genome-wide analyses of anthelmint
 ic resistance in helminths of livestock - Dr Roz Laing (University of Glas
 gow)
DTSTART:20220615T150000Z
DTEND:20220615T160000Z
UID:TALK173873@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Control of parasitic infections in animals and humans currentl
 y relies on mass drug administration of a limited number of anthelmintics.
  However\, this is not sustainable due to the emergence and spread of anth
 elmintic resistance. Haemonchus contortus is a highly pathogenic gastroint
 estinal nematode of small ruminants\, which is becoming increasingly diffi
 cult to control due to multi-drug resistance. The mechanisms underlying an
 thelmintic resistance are generally poorly understood\, with studies compa
 ring resistant and sensitive parasites confounded by high levels of geneti
 c diversity within and between and populations. To overcome this\, we cros
 sed a well-characterised multi-drug resistant isolate of H. contortus with
  a drug susceptible isolate to study resistance to three major anthelminti
 c classes\, while controlling for background variation. In this talk I wil
 l focus on our genomic and transcriptomic analyses of ivermectin resistanc
 e and describe ongoing work investigating the evolution of multi-drug resi
 stance in H. contortus and related parasites.\n\nThis talk will be broadca
 sted via Zoom. Please use this "link":https://zoom.us/j/95026514738?pwd=aU
 toam1zbDRYYWU0M1Nob2VPQXNvZz09 to gain access. 
LOCATION:Department of Pathology Lecture Theatre
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