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SUMMARY:Estimating global spatial dynamics and vaccine-induced fitness cha
 nges of Bordetella pertussis using genetic data. - Noemie Lefrancq (Univer
 sity of Cambridge)
DTSTART:20220504T150000Z
DTEND:20220504T160000Z
UID:TALK173936@talks.cam.ac.uk
CONTACT:Dr Ciara Dangerfield
DESCRIPTION:Bordetella pertussis (Bp)\, which causes whooping cough\, infe
 cts >24 million individuals annually despite widespread vaccination. Asymp
 tomatic carriage and multiple circulating lineages hide the underlying dyn
 amics of Bp from surveillance systems. Therefore\, the extent of spread ac
 ross spatial scales remains a mystery\, as does the role of vaccines in dr
 iving changes in strain fitness. Models informed by pathogen sequences can
  help. In this seminar I will present how models informed by >3300 genomes
  shed light on Bp spatial structure\, rate of geographic spread\, and fitn
 ess shifts in response to vaccine changes.\nLink to the paper: https://www
 .science.org/doi/10.1126/scitranslmed.abn3253
LOCATION:Zoom
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