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SUMMARY:CANCELLED!!!!!! Cell invasion: a casualty of dysregulated cell ext
 rusion   - Jody Rosenblatt\, Randall’s Division for Cell and Molecular B
 iophysics\, King’s College London.
DTSTART:20220606T133000Z
DTEND:20220606T143000Z
UID:TALK173957@talks.cam.ac.uk
CONTACT:Elena Scarpa
DESCRIPTION:Metastasis is the main cause of carcinoma-related death\, yet 
 we know little about how it initiates due to our inability to visualize st
 ochastic invasion events. Classical models suggest that cells accumulate m
 utations that first drive formation of a primary mass\, and then downregul
 ate epithelia-specific genes to cause invasion and metastasis. We use tran
 sparent zebrafish epidermis to model simple epithelia to directly image in
 vasion. We find that KRas-transformation\, implicated in early carcinogene
 sis steps\, directly drives cell invasion by hijacking a process epithelia
  normally use to promote death—cell extrusion. Cells invading by basal c
 ell extrusion simultaneously pinch off their apical epithelial determinant
 s\, endowing new plasticity. Mechanics not only drive dedifferentiation bu
 t also stromal cell differentiation\, as cells migrate through tight confi
 nement. Yet\, only invading KRasV12 cells deficient in p53 survive and for
 m internal masses. 
LOCATION:Online
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