BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Polyphasic linkage and the impact of ligand binding on the regulat
 ion of biomolecular condensates. - Dr Kiersten Ruff\, Washington Universit
 y in St. Louis
DTSTART:20220516T130000Z
DTEND:20220516T133000Z
UID:TALK174242@talks.cam.ac.uk
CONTACT:Jerelle Joseph
DESCRIPTION:Cellular matter can be spatially and temporally organized via 
 the formation of membraneless biomolecular condensates. Intermolecular int
 eractions among multivalent molecules\, known as scaffolds\, lead to phase
  separation and the formation of biomolecular condensates. Scaffold-driven
  phase separation can be regulated by titrating the concentration of regul
 atory molecules\, which we refer to as ligands. Polyphasic linkage\, intro
 duced by Wyman and Gill\, describes the linkage between ligand binding and
  the modulation of scaffold phase behavior. Using the framework of polypha
 sic linkage we utilize a stickers-and-spacers model to uncover features of
  ligands that promote or suppress scaffold-driven phase separation.  Our w
 ork also highlights how measuring dilute phase concentrations of scaffolds
  will be important for understanding the effects of ligands in cells. Over
 all\, insights gained from the application of polyphasic linkage concepts 
 should be useful for understanding biological and pharmaceutical regulatio
 n of condensates in vivo.\n\nhttps://zoom.us/j/92447982065?pwd=RkhaYkM5VTZ
 PZ3pYSHptUXlRSkppQT09 
LOCATION:Venue to be confirmed
END:VEVENT
END:VCALENDAR