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SUMMARY:The molecular mechanism of DNA crosslink repair - Pablo Alcon
DTSTART:20221020T121000Z
DTEND:20221020T130000Z
UID:TALK174518@talks.cam.ac.uk
CONTACT:Laura Pellegrini
DESCRIPTION:Our DNA is the manual of instructions that cells employ to gro
 w\, divide\, and even to die. This information must be faithfully passed o
 n\, generation after generation\, but it is continually threatened by radi
 ation\, chemicals\, and our own diet. Cells have developed clever defence 
 mechanisms to avoid and repair DNA damage. However\, these mechanisms can 
 fail\, giving rise to severe diseases. A special type of damage\, called D
 NA crosslink\, is normally repaired by our cells\, but patients suffering 
 the hereditary syndrome Fanconi Anemia (FA) fail to do so\, and suffer cat
 astrophic effects\, including fatal cancers. My goal is to understand the 
 molecular details of DNA crosslink repair\, and to do so I combine biochem
 istry\, biophysics and structural biology to visualise its underlying mech
 anisms at unprecedented detail. This will help us understand how this DNA 
 damage is normally repaired and why FA patients are unable to do so.
LOCATION:1 Newnham Terrace\, Darwin College
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