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SUMMARY:The awakening of the genome –modelling embryonic genome activati
 on programs in vitro - Jasmin Taubenschmid-Stowers
DTSTART:20221110T131000Z
DTEND:20221110T140000Z
UID:TALK174527@talks.cam.ac.uk
CONTACT:Dr Sandra Petrus-Reurer
DESCRIPTION:The activation of the zygotic genome (ZGA) marks the first maj
 or wave of transcription in the developing embryo and is crucial for devel
 opmental progression. To identify the molecular details of this process\, 
 we use stem cells to model ZGA in vitro. Using novel single cell sequencin
 g technologies in naïve embryonic stem cells\, we identified human 8-cell
  like cells (8CLCs)\, that resemble the human 8-cell embryo at the time of
  zygotic genome activation. 8CLCs represent a unique novel model system to
  study processes regulating human ZGA in vitro and will provide critical i
 nsights into early events in human embryogenesis in vivo.
LOCATION:1 Newnham Terrace\, Darwin College
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