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SUMMARY:SARS-CoV-2 evolution: (Dis)entangled on multiple scales - Simon Re
 lla\, Institute of Science and Technology Austria
DTSTART:20220525T150000Z
DTEND:20220525T160000Z
UID:TALK174710@talks.cam.ac.uk
CONTACT:Dr Ciara Dangerfield
DESCRIPTION:Evolutionary epidemiology is shaped by causes that span multip
 le orders of magnitude. For example: The fates of novel SARS-CoV-2 variant
 s depend on the societal interventions implemented\, while in turn those i
 nterventions are often direct reactions to adapted virus phenotypes. In or
 der to study certain aspects of this coupling\, we have developed a comput
 ational model\, which incorporates stochastic evolutionary events into an 
 epidemiological setting. We show that a combined effort of vaccination and
  non-pharmaceutical interventions is most effective at keeping a pathogen 
 from evolving vaccine resistance. This effect is further facilitated by so
 cietal aspects\, such as a greater diversity of vaccines distributed\, a f
 ast paced vaccine development and distribution as well as low levels of va
 ccine hesitancy. But also on the end of small scales\, biochemical aspects
  shape the viral fitness landscape and will influence the success of a vac
 cination campaign.
LOCATION:  Centre for Mathematical Sciences MR12\, CMS
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