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SUMMARY:CANCELLED: Dr Andrew Erickson: The spatial landscape of clonal som
 atic mutations in benign and malignant tissue - Dr Andrew Erickson\, Unive
 rsity of Helsinki\, Research Program in Systems Oncology (ONCOSYS) AND Uni
 versity of Oxford
DTSTART:20220708T123000Z
DTEND:20220708T133000Z
UID:TALK175964@talks.cam.ac.uk
CONTACT:Irena Rao
DESCRIPTION:Unfortunately this event has now been cancelled. We hope to re
 arrange the talk in autumn 2022.\nThe Early Cancer Institute is delighted 
 to welcome Dr Andrew Erickson to give a talk to our staff\, members and wi
 der network:\nPlease register at www.eventbrite.co.uk/e/362960002137\nDefi
 ning the transition from benign to malignant tissue is fundamental to impr
 ove early diagnosis of cancer. We used a systematic approach to study spat
 ial genome integrity in situ and describe previously unidentified clonal r
 elationships. We employed spatially resolved transcriptomics to infer spat
 ial copy number variations in >120\,000 regions across multiple organs\, i
 n benign and malignant tissues. We demonstrate that genome-wide copy numbe
 r variation reveals distinct clonal patterns within tumours and in nearby 
 benign tissue using an organ-wide approach focused on the prostate. Our re
 sults suggest a model for how genomic instability arises in histologically
  benign tissue that may represent early events in cancer evolution. We hig
 hlight the power of capturing the molecular and spatial continuums in a ti
 ssue context and challenge the rationale for treatment paradigms\, includi
 ng focal therapy. Pre-print: https://www.biorxiv.org/content/10.1101/2021.
 07.12.452018v1
LOCATION:Clifford Albutt Lecture Theatre\, Clinical School\, Addenbrooke's
  Hospital
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