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SUMMARY:Gut microbiome\, cognitive function and brain structure: a multi-o
 mics integration analysis - Jusheng Zheng\, School of Life Sciences\, West
 lake University\, China
DTSTART:20220622T120000Z
DTEND:20220622T130000Z
UID:TALK175994@talks.cam.ac.uk
CONTACT:Yuan Huang
DESCRIPTION:Microbiome-gut-brain axis may be involved in the progression o
 f age-related cognitive impairment and relevant brain structure changes\, 
 but evidence from large human cohorts is lacking. We aimed to investigate 
 the associations of gut microbiome with cognitive impairment and brain str
 ucture based on multi-omics from three independent populations. We include
 d 1430 participants from a prospective cohort study with both gut microbio
 me and cognitive assessment data available as a discovery cohort\, of whom
  272 individuals provided fecal samples twice before cognitive assessment.
  We selected 208 individuals with baseline microbiome data for brain magne
 tic resonance imaging during the follow-up visit. The validation analyses 
 were conducted in an Alzheimer’s disease case-control study (replication
  study 1\, n=90) and another community-based cohort (replication study 2\,
  n=1300) with cross-sectional dataset. Our findings reveal that specific g
 ut microbial features are closely associated with cognitive impairment and
  decreased hippocampal volume\, which may play an important role in dement
 ia development.\n\n*Join Zoom Link:*\n\nhttps://maths-cam-ac-uk.zoom.us/j/
 93331132587?pwd=MlpReFY3MVpyVThlSi85TmUzdTJxdz09\nMeeting ID: 933 3113 258
 7\nPasscode:  144696\n
LOCATION:Virtual (see abstract for Zoom link)
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