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SUMMARY:CPB Seminar - Kevin Chalut - Kevin Chalut (Wellcome-MRC Cambridge 
 Stem Cells Institute)
DTSTART:20220623T130000Z
DTEND:20220623T140000Z
UID:TALK176048@talks.cam.ac.uk
CONTACT:Margarida Rodrigues
DESCRIPTION:Mechanobiology of cell fate choice\n\nThe role of mechanics in
  cell fate choice has been largely overlooked\; however\, mechanics plays 
 a significant role in getting the right cells to the right place at the ri
 ght time in development. My lab is investigating the interplay between mec
 hanics and signaling in cell fate decisions\, both in stem cells and the e
 mbryo. I will present our work showing how cell surface mechanics influenc
 es early embryonic spatial patterning and fate transitions in the mouse em
 bryo. I will also show how cell surface mechanics particularly impacts sig
 nalling that is instructive for cell fate choice. I will ultimately presen
 t a hypothetical feedback loop between mechanics and signaling that has si
 gnificant impact on cellular plasticity both in development and stem cells
 . 
LOCATION:Sainsbury Laboratory \, Auditorium\, 47 Bateman Street \, CB2 1LR
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