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SUMMARY:Local Therapeutic Delivery for Brain Cancer - Dr Ryan Mathew\, Ass
 ociate Professor\, Honorary Consultant Neurosurgeon\, University of Leeds
DTSTART:20220708T100000Z
DTEND:20220708T110000Z
UID:TALK176327@talks.cam.ac.uk
CONTACT:Kirsty Shepherd
DESCRIPTION:Glioma is a brain cancer of unmet need. Despite current best t
 reatment\, median overall survival remains dismal at 12-15 months. Maximal
  safe resection is the preferred first step in glioma management. However\
 , the tumour cavity is surrounded by infiltrative cancer cells that resist
  adjuvant chemoradiotherapy\, and drive recurrence. Surgical targeting of 
 these cells is limited by their intermingling with healthy and/or eloquent
  brain. Limited biological models exist to study this so-called ‘margin 
 zone.’ The Stem Cells and Brain Tumour Group at Leeds (co-led by Ryan Ma
 thew and Heiko Wurdak)\, in conjunction with Academic Surgery\, is develop
 ing new in vitro and in vivo models to study the ‘margin zone’ and als
 o devise new local therapeutic interventions that can be deployed at the t
 ime of surgery. Examples include hydrogels\, nanofibres\, ultra-high preci
 sion laser and tumour-treating fields.
LOCATION:Cambridge Graphene Centre Seminar Room
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