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SUMMARY:Axon guidance and local RNA-based mechanisms of directional steeri
 ng - Christine Holt Department of Physiology\, Development and Neuroscienc
 e\, Anatomy Building\, Downing Street\, University of Cambridge\, Cambridg
 e CB2 3DY
DTSTART:20090331T131000Z
DTEND:20090331T135500Z
UID:TALK17642@talks.cam.ac.uk
CONTACT:Anna Di Pietro
DESCRIPTION:Synaptic connections between distant neurons are first establi
 shed by axons navigating along specific pathways. A key aspect of this nav
 igation is its remarkable accuracy and we are trying to understand the mol
 ecular and cellular basis of this precision-guided growth. Early pathways\
 , while physically continuous\, are sub-divided into molecularly distinct 
 domains and growing axons are guided from one segment to the next by succe
 ssive encounters with guidance cues. The motile tip of growing axons\, the
  growth cone\, contains mRNAs and translation machinery and guidance cues 
 such as netrin and semaphorin elicit rapid protein synthesis in growth con
 es. This lecture will focus on an RNA-based mechanism of directional steer
 ing in Xenopus retinal axons with particular consideration of the role of 
 spatially localised translation.
LOCATION:Cripps Court\, Magdalene College
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