BEGIN:VCALENDAR VERSION:2.0 PRODID:-//Talks.cam//talks.cam.ac.uk// X-WR-CALNAME:Talks.cam BEGIN:VEVENT SUMMARY:Deciphering gene expression regulation in health and disease using integrative omics approaches - Prof Michiel Vermeulen\; Radboud Universit y DTSTART:20220914T123000Z DTEND:20220914T133000Z UID:TALK176474@talks.cam.ac.uk CONTACT:Bobbie Claxton DESCRIPTION:The development of an adult human being from a single fertiliz ed egg is accompanied by the generation of ~200 functionally distinct cell types. Each of these cell types expresses only a subset of the 20.000 gen es that the human genome encodes for. Cell-type specific gene expression p atterns thus ensure the generation of hundreds of phenotypes based on a si ngle genotype. Transcription factors play an important role in driving cel l-type specific gene expression\, but so-called epigenetic modifications o f DNA and core histones also regulate changes in gene expression and pheno type during development and during adult life. Our lab is integrating stat e-of-the-art quantitative mass-spectrometry based (interaction) proteomics and next generation DNA sequencing technology to decipher (epi)genetic re gulation of gene expression in (differentiated) stem cells. In my lecture I will provide an overview of some of our recent results related to these topics. \n\nMichiel Vermeulen performed his doctoral work in the laborato ry of Henk Stunnenberg at the University of Nijmegen in the Netherlands. I n 2005 he joined the lab of Matthias Mann in Munich\, Germany as a post-do ctoral fellow. In 2009 he was appointed as assistant professor and in 2013 as associate professor at the University Medical Center Utrecht in The Ne therlands. In February 2014 he was appointed as full professor at the Radb oud University in Nijmegen\, The Netherlands. He is the current research d irector of the RIMLS-Science institute at the Radboud University. He is al so one of the founding members of the Oncode Institute. In 2022 he was ele cted as member of EMBO. \n\nClick here to join live - https://us06web.zoom .us/j/81723173978 LOCATION:Online via zoom &\; Kings Hedges Room END:VEVENT END:VCALENDAR