BEGIN:VCALENDAR
VERSION:2.0
PRODID:-//Talks.cam//talks.cam.ac.uk//
X-WR-CALNAME:Talks.cam
BEGIN:VEVENT
SUMMARY:Simple solutions to complex problems: from cell cycle regulation t
 o anti-cancer treatments - Dr Adrian Saurin\; University of Dundee
DTSTART:20221005T123000Z
DTEND:20221005T133000Z
UID:TALK176492@talks.cam.ac.uk
CONTACT:Bobbie Claxton
DESCRIPTION:My lab investigates how signalling networks regulate cell cycl
 e transitions and how these can be targeted to treat cancer. Our work span
 s fundamental to translational research and I will cover both of these are
 as in the two parts of my seminar.\n\nPart I: The origins of complexity in
  protein phosphorylation networks. I will start by discussing a fundamenta
 l property that is common to all phosphorylation sites\, but for which alm
 ost nothing is currently known: the rate that these sites can “flash” 
 on and off over time. I will briefly highlight how we plan to tackle this 
 problem over the coming years\, before presenting our recent unpublished d
 ata on a bifunctional kinase-phosphatase module that induces such dynamic 
 phosphorylation-dephosphorylation cycles to coordinate two key mitotic pro
 cesses.\n·	\nPart II: Cell cycle inhibitors can switch an oncogene into a
  tumour suppressor. I will then switch focus to highlight how understandin
 g simple concepts in cell cycle and growth control can help to answer an a
 ge-old question in cancer research: how can cell cycle inhibitors be used 
 to selectively target cancer cells? The work I will present\, which is als
 o largely unpublished\, will explain how CDK4/6 inhibitors can induce sele
 ctive toxicity in tumour cells that are primed for oncogenic cell growth. 
 \n\nClick here to join live - https://us06web.zoom.us/j/89875462178 
LOCATION:Online via zoom &amp\; Kings Hedges Room 
END:VEVENT
END:VCALENDAR