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SUMMARY:Functional imaging in stroke - Jean-Claude Baron Department of Cli
 nical Neurosciences\, University of Cambridge\, R3 Neurosciences Addenbroo
 ke's Hospital\, Cambridge UK
DTSTART:20090401T133000Z
DTEND:20090401T141500Z
UID:TALK17651@talks.cam.ac.uk
CONTACT:Anna Di Pietro
DESCRIPTION:In people surviving from ischaemic stroke\, recovery of functi
 on is almost consistently observed. Rapid recovery can take place In the f
 irst few days\, while subsequently recovery slows down but can continue fo
 r months and even years. However\, the temporal pattern and extent of reco
 very is highly variable from subject to subject. Understanding the mechani
 sms underlying this individual variability would help design improved ther
 apy to speed up recovery and/or enhance final outcome. Functional imaging 
 in patients\, and parallel animal studies\, has led to major advances in u
 nderstanding the pathophysiological bases of recovery from stroke. In stro
 ke affecting the cortex\, functional imaging has shown that reperfusion of
  the ischaemic penumbra explains most of the early recovery\, but also app
 ears to sustain a large part of\, subsequent clinical recovery by allowing
  preserved peri-infarct neurons to compensate for the damaged area\, perha
 ps via unmasking of normally “silent” representations. After pure sub-
 cortical stroke\, adaptation of overlying cortical areas to deafferentatio
 n has been documented\, and shown to underlie clinical recovery. In additi
 on\, redistribution of function and reorganisation of remote functional ne
 tworks\, including contralesional areas\, has also been documented after b
 oth cortical and subcortical strokes. Illustration of these mechanisms\, a
 nd results from studies currently underway in the lab addressing e.g. tapp
 ing regularity\, mirror movements\, motor imagery and analysis of connecti
 vity\, will be presented.\n
LOCATION:Cripps Court\, Magdalene College
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