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SUMMARY:Functional imaging of cortical connectivity in normal brain and ne
 urodegenerative disease - James Rowe Cambridge University Centre for Brain
  Repair\, University of Cambridge\, Cambridge\, UK
DTSTART:20090401T141500Z
DTEND:20090401T150000Z
UID:TALK17652@talks.cam.ac.uk
CONTACT:Anna Di Pietro
DESCRIPTION:Neurons and regional neuronal populations do not work in isola
 tion. Rather\, they are part of integrated neuronal networks\, including b
 oth local and widely distributed networks. If one wishes to understand the
  complex effects of aging\, focal lesions or neurodegeneration on brain fu
 nction\, one needs to include an assessment of the changes of connectivity
  within brain networks. A variety of methods are now readily available to 
 characterise network connectivity based on magnetic resonance imaging data
 . \nThe applications of several connectivity methods to analyse fMRI data 
 will be illustrated. These include psychophysiological interactions\, stru
 ctural equation modelling and dynamic causal modelling. We will see how th
 ese methods give a richer understanding of the consequences of stroke\, fo
 cal lesions\, aging and Parkinson’s disease: an understanding that could
  not have been achieved from behavioural data or standard imaging methods.
  The changes in connectivity will be cautiously interpreted in terms of ne
 uroplasticity\, and related to assessment of novel strategies for restorat
 ive neurology. \n\n
LOCATION:Cripps Court\, Magdalene College
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