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SUMMARY:A systems approach to recovery of function - Cornelius Weiller Dep
 artment of Neurology\, Freiburg University\, Freiburg\, Germany
DTSTART:20090402T104500Z
DTEND:20090402T113000Z
UID:TALK17656@talks.cam.ac.uk
CONTACT:Anna Di Pietro
DESCRIPTION:Brain’s functions are mainly organised in distributed\, segr
 egated and overlapping networks\, comprising of nodes and interconnections
 . The functional properties of an area are determined by its connections. 
 The various areas are not independent from each other. Their respective fu
 nctions can only be understood in relation to the other parts of the netwo
 rk. Reorganisation due to lesions or intervention mainly takes place withi
 n the framework of these networks. The effects of lesions\, dysfunction an
 d stimulation or intervention depend on the pre- existing individual netwo
 rk architecture and the site and type of intervention.\nWe use a new appli
 cation of probalistic fibre tracking on DTI data to describe the anatomica
 l course of connections between fMRI hot spots (as network nodes) in combi
 nation with measurements of effective connectivity with partial directed c
 orrelations to determine functionally defined brain networks in the domain
 s of motor\, language and attention. Application to fMRI data of stroke pa
 tients with hemiplegia\, aphasia or neglect identifies “critical lesions
 ” and tries to predict changes in reorganisation after stroke.\n\n
LOCATION:Cripps Court\, Magdalene College
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