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SUMMARY:Navigating the maze: transport through intracellular tubule networ
 ks - Prof Elena Koslover\, UC San Diego
DTSTART:20220720T140000Z
DTEND:20220720T150000Z
UID:TALK176630@talks.cam.ac.uk
CONTACT:George Fortune
DESCRIPTION:The intracellular environment contains a variety of complex mo
 rphologies that can substantially affect the transport\, distribution\, an
 d kinetics of particles within the cell. In this talk\, we will focus on o
 rganelle structures that form interconnected networks of tubules -- specif
 ically on mitochondrial and endoplasmic reticulum (ER) networks. The ER pl
 ays a crucial role in several cellular processes\, including protein quali
 ty control and calcium homeostasis\, which require the transport of protei
 ns and ligands through the tubular network. Using a combination of analyti
 c results and numerical simulations we explore how network morphology gove
 rns encounter and target-search rates for diffusing particles confined in 
 the network. We quantify the transport of membrane and luminal proteins fr
 om the measured spatiotemporal evolution of photoactivated protein densiti
 es\, provided by collaborating groups. Finally\, we identify the role of t
 ransport and network architecture in local release and refilling of ER cal
 cium storage\, combining buffered kinetics with diffusion through a networ
 k. Overall\, our exploration of the interplay between transport dynamics\,
  organelle morphology\, and reaction kinetics helps elucidate the structur
 e-function relationships of key cellular components such as the endoplasmi
 c reticulum.
LOCATION:MR2\,  Centre for Mathematical Sciences\, Wilberforce Road\, Camb
 ridge
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