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SUMMARY:SchistoTrack: A community-based\, prospective cohort in rural Ugan
 da to examine causes of periportal fibrosis associated with hepatic schist
 osomiasis - Dr Goylette Chami
DTSTART:20230309T160000Z
DTEND:20230309T170000Z
UID:TALK177401@talks.cam.ac.uk
CONTACT:Anna Protasio
DESCRIPTION:Abstract:\nPeriportal fibrosis is a severe morbidity associate
 d with intestinal schistosomiasis\, including Schistosoma mansoni and S. j
 aponicum. These parasitic blood flukes live in the mesenteric venules. The
  eggs produced by mature female flukes must traverse the intestinal mucosa
  to be excreted. Only ~50% of the eggs are successfully excreted with the 
 remaining eggs being swept back into the liver and spleen. The inflammatio
 n\, granulomas\, and subsequent fibrosis in and around the portal veins co
 ntributes to vascular restructuring within the liver and distinct patterns
  of fibrosis associated with intestinal schistosomiasis. Understanding the
  risk factors and predictors of progression within and across individuals 
 is challenging due to imperfect diagnostics\, confounders of ongoing treat
 ment\, and interacting co-infections within the liver. \n\nSchistoTrack is
  a community-based\, prospective cohort in Eastern and Western Uganda that
  aims to assess the within and across individual causes of periportal fibr
 osis. Nearly ~4000 individuals in 52 rural villages are being followed up 
 over five years with detailed clinical examinations and a further ~6000 in
 dividuals are assessed with detailed medical histories. This talk will int
 roduce the SchistoTrack Cohort and share preliminary findings on the risk 
 factors for periportal fibrosis\, including challenges of diagnosis within
  a cohort setting and the contributions of coinfections. \n\nBio:\nDr. Cha
 mi is an Associate Professor and Robertson Fellow in the Big Data Institut
 e and Nuffield Department of Population Health. Her work combines advanced
  statistics and machine learning with field epidemiology and parasitology 
 to improve clinical outcomes in East Africa. She leads the Oxford-Uganda C
 ollaboration on Schistosomiasis and the SchistoTrack Cohort. Dr. Chami hol
 ds advisory roles for the World Health Organisation on diagnostics and sur
 veillance for neglected tropical diseases in the cross-cutting disease sub
 group. She has been endorsed as an Exceptional Promise Academic by the Roy
 al Society in clinical public health\, profiled by Nature for her research
  contributions to infectious disease epidemiology\, and awarded the Odile 
 Bain Memorial Prize for advances in medical parasitology. She previously h
 eld fellowships and completed MPhil and PhD degrees at the University of C
 ambridge. \n\nThis talk will be broadcasted via Zoom. Please use this "lin
 k":https://zoom.us/j/94465280694?pwd=YU50RVFCZjM5RXJhanEzSTM3YkN6UT09 to g
 ain access. 
LOCATION:Seminar Room\, Tennis Court Road\, Dept of Pathology.
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