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SUMMARY:Genetic studies of epigenetic clocks in different species - Profes
 sor Steve Horvath from Department of Biostatistics\, UCLA School of Public
  Health\, Los Angeles\, CA  
DTSTART:20230112T140000Z
DTEND:20230112T150000Z
UID:TALK177794@talks.cam.ac.uk
CONTACT:Caroline Newnham
DESCRIPTION:Cytosine methylation lends itself for building universal epige
 netic clocks that apply to all mammalian tissues and cell types and to est
 imate species characteristics such as maximum lifespan.\n\nI will review w
 hat has been learnt about the mechanism underlying epigenetic clocks based
  on genetic and non-genetic interventions that affect epigenetic aging rat
 es.  I will describe several rejuvenating interventions including the tran
 sient application of reprogramming factors.\n\nGenomewide association stud
 ies of epigenetic age acceleration shed light on the genetic underpinnings
  of the epigenetic clock. The epigenetic clock method has been used to stu
 dy accelerated aging disorders (progeria\, Down syndrome\, overgrowth diso
 rders) and conversely conditions that seem to be associated with slow agin
 g (dwarf mice).  \n\nI will present results from the Mammalian Methylation
  Consortium based on 13\,000 samples derived from 348 mammalian species an
 d 25 taxonomic orders. Positively age related cytosines are greatly enrich
 ed in polycomb repressive complex 2-binding sites\, and are proximal to ge
 nes that play a role in mammalian development\, cancer\, human obesity\, a
 nd human longevity. Methylation sites that correlated to maximum lifespan 
 were enriched at HOX genes\, indicating a link between developmental proce
 sses and maximum lifespan. Overall\, these studies highlight the key role 
 of epigenetics in the evolution of life history traits\, and advance the m
 olecular understanding of mammalian lifespan.
LOCATION:Biffen Lecture theatre and Zoom
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